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It is suggested that the observed increase in stoichiometric
The chemical synthesis of whole proteins is addressed in Part II steriods, and current progress in the field is reviewed (Chapter 4). Work towards the total chemical synthesis of acyl carrier protein using a two fragment approach is described in Chapter 5. The N terminal fragment was synthesized using the sulfonamide linker, and while the C terminal fragment presented difficulties due to extremely low solubility, solubilization using backbone protection was demonstrated.
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